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Biography

Dr. Yang Fu is a Tenured Associate Professor and Principal Investigator in the Department of Biochemistry at the Southern University of Science and Technology (SUSTech) School of Medicine, as well as a doctoral supervisor. He is a recipient of the National Young Talent Program and the Shenzhen Peacock Talent Award. Currently, he serves as the Deputy Director of the SUSTech Biosafety Platform and is a member of the Shenzhen Science and Technology Innovation Commission's Expert Committee on New Drugs and Vaccines.

Dr. Fu received his Ph.D. in Biochemistry and Molecular Biology from Nankai University in 2013, and participated in a joint Ph.D. training program in Microbiology at Harvard Medical School from 2008 to 2013. He studied under world-renowned microbiologist and U.S. National Academy of Sciences member, Professor John Mekalanos.

Since establishing his independent research group at SUSTech in 2019, Dr. Fu’s team has focused on bacterial macromolecular transmembrane delivery systems, investigating their activation mechanisms, dynamic actions, effector protein mechanisms, functional analysis of genetic elements, and prokaryotic-eukaryotic interactions. The team conducts in-depth theoretical research while also bridging findings to applied translational directions. In response to national and municipal calls, the group also leverages its expertise in pathogenic microbiology to conduct emergency research on emerging infectious diseases such as SARS-CoV-2 and monkeypox.

The research is distinctly characterized by studies on two typical “injectable secretion systems” in Gram-negative bacteria: the Type VI Secretion System (T6SS) and the extracellular contractile injection system (eCIS). Research directions include: 1) precise antibacterial mechanisms and strategies, 2) targeted protein delivery at the cellular level, and 3) synthetic biology applications. To date, Dr. Fu’s team has published 39 research papers (31 from SUSTech), including 21 high-impact papers as corresponding or first author in journals such as Cell Host & Microbe (3 papers), Molecular Cell, PNAS, Gut Microbes, Advanced Functional Materials, Journal of Biological Chemistry (2 papers), Microbiological Research (2 papers), and mLife. His publications have been cited over 5,700 times. The team has applied for 7 technical invention patents, one of which has already achieved industrial translation valued at RMB 3 million.

The group has led more than 20 research projects funded by the National Natural Science Foundation of China (General and Youth Programs), the Organization Department of the CPC Central Committee, the Guangdong Province Basic and Applied Basic Research Foundation, the Shenzhen Science and Technology Innovation Commission (Key Fundamental Research Projects, Peacock Team Project, Emergency COVID-19 Research Key Program), and the Shenzhen Medical Academy of Research and Translation (SMART), among others. The team maintains ample research funding.

Academic tenure

1、magazine editor of Bio-Protocol

Awards

1、National talent titles

2、Shenzhen's  talent titles

3、Fogarty Global Health Fellowship

Educational experience

1、2001.09-2005.06  Bachelor ,Jiangnan University

2、2006.09-2013.06  Doctor , Nankai University

3、2009.09-2013.05  Joint Doctor of Education ,Harvard University

Work experience：

1、2005.07-2006.08  Technician, Nankai University

2、2008.06-2009.01  Visiting Scholar , School of Public Health，Harvard University

3、2013.07-2018.06  Postdoctoral researcher , School of Medicine，Harvard University

4、2018.07-2019.06  Assistant researcher, School of Medicine，Harvard University

5、2019.06-2020.12，Assistant professor / PhD Tutor, Southern University of Science and Technology

6、2020.12-present，Associate professor / PhD Tutor, Southern University of Science and Technology

Representative papers：

* Contributed equally to the work and # for corresponding authors

Representative papers at SUSTech as a Corresponding author:

1. Liu M, Wang H, Wang Z, Wang H, Zhang K, Xue J, Liu R, Liu Y, Xia P, Wang H, Kan B, Li Y, Li S, Fu Y#. A Vibrio-specific T6SS effector reshapes microbial competition by disrupting Vibrio bioenergetics. Cell Host and Microbe. 2025; 33(7): 1146-1160. e8.

2. Liu RH*, Zhang K*, Feng QS, He SJ, Fan QY, Zhang X, Li W, Bao ZP, Lin WF, Fu Y#, Li Y#. Unveiling Acidophilic Secretin Nanopores for Ion Exclusion and Single-molecule Sensing. Advanced Functional Materials. 2025, in press.

3. Wang H, Liu Y, Wang Z, Xia P, Li Z, Liu M#, Fu Y#. Functional Insights into the Type VI Secretion System of Multi-drug Resistant Aeromonas hydrophila: A Key Factor in Competition and Pathogenesis. mLife. 2025; 4(4): 363-377.

4. Guo HH, Zhang Q, Wang Z, Zhang K#, Fu Y#. Structural insight into Vibrio cholerae EIIC Sugar Transporter Dimer Captured in a Substrate-Free Inward-facing State. Acta Biochimica et Biophysica Sinica. 2025; 57(x):1-8.

5. Feng Q, Dai, X, Wu, Q, Zhang L#, Yang L#, Fu Y#. C-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in Pseudomonas aeruginosa. mSphere. 2025; e01026-24.

6. Xiang Q, Wu J, Zhou Y, Li L, Tian M, Li G#, Zhang Z#, Fu Y#. SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin. Microbiol Res. 2024; 282:127659.

7. Feng Q, Zhou J, Zhang L, Fu Y#, Yang L#. Insights into the molecular basis of c-diGMP signalling in Pseudomonas aeruginosa. Crit Rev Microbiol. 2024; 50(1): 20-38.

8. Yu B*, Lu Q*, Li J*, Cheng X*, Hu H, Li Y, Che T, Hua Y, Jiang H, Zhang Y, Xian C, Yang T, Fu Y, Chen Y, Nan W, McCormick PJ, Xiong B, Duan J, Zeng B, Li Y#, Fu Y#, Zhang J#. Cryo-EM structure of human HCN3 channel and its regulation by cAMP. J Biol Chem. 2024; 300(6): 107288.

9. Zhang Y*, Wang D*, Xiang Q*, Hu X, Zhang Y, Wu L, Zhang Z, Wang Y, Zhao J, McCormick PJ, Fu J#, Fu Y#, Zhang J#, Jiang H#, Li J#. A potent neutralizing nanobodytargeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein. Virology. 2024; 589: 109925.

10. Liu M*, Wang H*, Liu Y, Tian M, Wang Z, Shu RD, Zhao MY, Chen WD, Wang H, Wang H, Fu Y#. The phospholipase effector Tle1(Vc) promotes Vibrio cholerae virulence by killing competitors and impacting gene expression. Gut Microbes. 2023; 15(1): 2241204.

11. Liu M*, Zhao MY*, Wang H, Wang ZH, Wang Z, Liu Y, Li YP, Dong T, Fu Y#. Pesticin-Like Effector VgrG3(cp) Targeting Peptidoglycan Delivered by the Type VI Secretion System Contributes to Vibrio cholerae Interbacterial Competition. Microbiol Spectr. 2023; 11(1): e0426722.

12. Zhang K*, Peng T*, Tao X*, Tian M*, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Luo J, Wu Q, Fu Y#, Li S#. Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol Cell. 2022; 82(24): 4712-4726. e4717.

13. Xiang Q, Li L, Wu J, Tian M, Fu Y#. Application of pseudovirus system in the development of vaccine, antiviral-drugs, and neutralizing antibodies. Microbiol Res. 2022; 258: 126993.

14. Song X*, Li J*, Tian M*, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y#, Duan J#, Zhang J#. Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. J Biol Chem. 2022; 298(2): 10148.

15. Chen Y*, Wang S*, Huang J*, Fu Y, Wen J, Zhou C, Fu Y#, Liu L#. Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19. Clin Hemorheol Microcirc. 2021; 78(2): 199-207.

16. Cai Q*, Huang D*, Ou P*, Yu H, Zhu Z, Xia Z, Su Y, Ma Z, Zhang Y, Li Z, He Q, Liu L#, Fu Y#, Chen J#. COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy. 2020; 75(7): 1742-1752.

    
    

    Before joining SUSTech

17. Fu Y*, Ho BT*, Mekalanos JJ#. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell Host and Microbe. 2018; 23(2): 274-281 e272.

18. Ho BT*, Fu Y*, Dong TG, Mekalanos JJ#. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci USA. 2017; 114(35): 9427-9432.

19. Fu Y, Waldor MK, Mekalanos JJ#. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host and Microbe. 2013; 14(6): 652-663.